diff --git a/ddtrace/internal/forksafe.py b/ddtrace/internal/forksafe.py
index 62a8371e4b0..6b311de6025 100644
--- a/ddtrace/internal/forksafe.py
+++ b/ddtrace/internal/forksafe.py
@@ -7,6 +7,7 @@
 import typing
 import weakref
 
+from ddtrace.internal.module import ModuleWatchdog
 from ddtrace.vendor import wrapt
 
 
@@ -22,6 +23,25 @@
 _soft = False
 
 
+def patch_gevent_hub_reinit(module):
+    # The gevent hub is re-initialized *after* the after-in-child fork hooks are
+    # called, so we patch the gevent.hub.reinit function to ensure that the
+    # fork hooks run again after this further re-initialisation, if it is ever
+    # called.
+    from ddtrace.internal.wrapping import wrap
+
+    def wrapped_reinit(f, args, kwargs):
+        try:
+            return f(*args, **kwargs)
+        finally:
+            ddtrace_after_in_child()
+
+    wrap(module.reinit, wrapped_reinit)
+
+
+ModuleWatchdog.register_module_hook("gevent.hub", patch_gevent_hub_reinit)
+
+
 def ddtrace_after_in_child():
     # type: () -> None
     global _registry
diff --git a/riotfile.py b/riotfile.py
index 418d888838b..ea6ea85fb86 100644
--- a/riotfile.py
+++ b/riotfile.py
@@ -246,6 +246,7 @@ def select_pys(min_version=MIN_PYTHON_VERSION, max_version=MAX_PYTHON_VERSION):
                         "structlog": latest,
                         # httpretty v1.0 drops python 2.7 support
                         "httpretty": "==0.9.7",
+                        "gevent": latest,
                     },
                 )
             ],
diff --git a/tests/tracer/test_forksafe.py b/tests/tracer/test_forksafe.py
index 756675d8dc5..367af80d3b2 100644
--- a/tests/tracer/test_forksafe.py
+++ b/tests/tracer/test_forksafe.py
@@ -1,4 +1,5 @@
 import os
+import sys
 
 import pytest
 import six
@@ -285,3 +286,59 @@ def fn():
     pid, status = os.waitpid(child, 0)
     exit_code = os.WEXITSTATUS(status)
     assert exit_code == 42
+
+
+@pytest.mark.subprocess(
+    out="" if (3,) < sys.version_info < (3, 7) else ("CTCTCT" if sys.platform == "darwin" else "CCCTTT"),
+    err=None,
+)
+def test_gevent_reinit_patch():
+    import os
+    import sys
+
+    from ddtrace.internal import forksafe
+    from ddtrace.internal.periodic import PeriodicService
+
+    class TestService(PeriodicService):
+        def __init__(self):
+            super(TestService, self).__init__(interval=1.0)
+
+        def periodic(self):
+            sys.stdout.write("T")
+
+    service = TestService()
+    service.start()
+
+    def restart_service():
+        global service
+
+        service.stop()
+        service = TestService()
+        service.start()
+
+    forksafe.register(restart_service)
+
+    import gevent  # noqa
+
+    def run_child():
+        global service
+
+        # We mimic what gunicorn does in child processes
+        gevent.monkey.patch_all()
+        gevent.hub.reinit()
+
+        sys.stdout.write("C")
+
+        gevent.sleep(1.5)
+
+        service.stop()
+
+    def fork_workers(num):
+        for _ in range(num):
+            if os.fork() == 0:
+                run_child()
+                sys.exit(0)
+
+    fork_workers(3)
+
+    service.stop()