diff --git a/ddtrace/__init__.py b/ddtrace/__init__.py
index 0250cf32381..6c3c65b3f2b 100644
--- a/ddtrace/__init__.py
+++ b/ddtrace/__init__.py
@@ -1,4 +1,9 @@
-from ._logger import configure_ddtrace_logger
+from ddtrace.internal.module import ModuleWatchdog
+
+
+ModuleWatchdog.install()
+
+from ._logger import configure_ddtrace_logger  # noqa: E402
 
 
 # configure ddtrace logger before other modules log
diff --git a/tests/internal/test_module.py b/tests/internal/test_module.py
index d9c0b11ecff..855f571339d 100644
--- a/tests/internal/test_module.py
+++ b/tests/internal/test_module.py
@@ -9,6 +9,22 @@
 import tests.test_module
 
 
+@pytest.fixture(autouse=True, scope="module")
+def ensure_no_module_watchdog():
+    # DEV: The library might use the ModuleWatchdog and install it at a very
+    # early stage. This fixture ensures that the watchdog is not installed
+    # before the tests start.
+    was_installed = ModuleWatchdog.is_installed()
+    if was_installed:
+        ModuleWatchdog.uninstall()
+
+    try:
+        yield
+    finally:
+        if was_installed:
+            ModuleWatchdog.install()
+
+
 @pytest.fixture
 def module_watchdog():
     ModuleWatchdog.install()
@@ -65,8 +81,6 @@ def test_import_origin_hook_for_module_not_yet_imported():
     path = os.getenv("MODULE_ORIGIN")
     hook = mock.Mock()
 
-    ModuleWatchdog.install()
-
     ModuleWatchdog.register_origin_hook(path, hook)
 
     hook.assert_not_called()
@@ -100,8 +114,6 @@ def test_import_module_hook_for_module_not_yet_imported():
     name = "tests.test_module"
     hook = mock.Mock()
 
-    ModuleWatchdog.install()
-
     ModuleWatchdog.register_module_hook(name, hook)
 
     hook.assert_not_called()
@@ -136,8 +148,6 @@ def test_module_deleted():
     path = os.getenv("MODULE_ORIGIN")
     hook = mock.Mock()
 
-    ModuleWatchdog.install()
-
     ModuleWatchdog.register_origin_hook(path, hook)
     ModuleWatchdog.register_module_hook(name, hook)
 
@@ -327,3 +337,5 @@ def test_module_watchdog_dict_shallow_copy():
 
     # Ensure that they match
     assert original_modules == new_modules
+
+    ModuleWatchdog.uninstall()
diff --git a/tests/profiling/collector/test_threading.py b/tests/profiling/collector/test_threading.py
index e2288ba1be1..8b56941f483 100644
--- a/tests/profiling/collector/test_threading.py
+++ b/tests/profiling/collector/test_threading.py
@@ -72,7 +72,7 @@ def test_lock_acquire_events():
     # It's called through pytest so I'm sure it's gonna be that long, right?
     assert len(event.frames) > 3
     assert event.nframes > 3
-    assert event.frames[0] == (__file__, 65, "test_lock_acquire_events")
+    assert event.frames[0] == (__file__.replace(".pyc", ".py"), 65, "test_lock_acquire_events")
     assert event.sampling_pct == 100
 
 
@@ -187,7 +187,7 @@ def test_lock_release_events():
     # It's called through pytest so I'm sure it's gonna be that long, right?
     assert len(event.frames) > 3
     assert event.nframes > 3
-    assert event.frames[0] == (__file__, 180, "test_lock_release_events")
+    assert event.frames[0] == (__file__.replace(".pyc", ".py"), 180, "test_lock_release_events")
     assert event.sampling_pct == 100
 
 
@@ -217,7 +217,7 @@ def play_with_lock():
             # It's called through pytest so I'm sure it's gonna be that long, right?
             assert len(event.frames) > 3
             assert event.nframes > 3
-            assert event.frames[0] == (__file__, 200, "play_with_lock")
+            assert event.frames[0] == (__file__.replace(".pyc", ".py"), 200, "play_with_lock")
             assert event.sampling_pct == 100
             assert event.task_id == t.ident
             assert event.task_name == "foobar"
@@ -234,7 +234,7 @@ def play_with_lock():
             # It's called through pytest so I'm sure it's gonna be that long, right?
             assert len(event.frames) > 3
             assert event.nframes > 3
-            assert event.frames[0] == (__file__, 201, "play_with_lock")
+            assert event.frames[0] == (__file__.replace(".pyc", ".py"), 201, "play_with_lock")
             assert event.sampling_pct == 100
             assert event.task_id == t.ident
             assert event.task_name == "foobar"
diff --git a/tests/profiling/collector/test_traceback.py b/tests/profiling/collector/test_traceback.py
index ac9712522f6..f6d7fa3ff71 100644
--- a/tests/profiling/collector/test_traceback.py
+++ b/tests/profiling/collector/test_traceback.py
@@ -14,11 +14,9 @@ def test_check_traceback_to_frames():
         exc_type, exc_value, traceback = sys.exc_info()
     frames, nframes = _traceback.traceback_to_frames(traceback, 10)
     assert nframes == 2
+
+    this_file = __file__.replace(".pyc", ".py")
     assert frames == [
-        (__file__, 7, "_x"),
-        (
-            __file__,
-            15,
-            "test_check_traceback_to_frames",
-        ),
+        (this_file, 7, "_x"),
+        (this_file, 15, "test_check_traceback_to_frames"),
     ]