diff --git a/test/e2e/cross_tool_integration/workflow_test.ts b/test/e2e/cross_tool_integration/workflow_test.ts
index 968ae304cab..2d2690dc7f5 100644
--- a/test/e2e/cross_tool_integration/workflow_test.ts
+++ b/test/e2e/cross_tool_integration/workflow_test.ts
@@ -102,7 +102,8 @@ describe('A user can move tabs', function() {
 });
 
 describe('A user can open panels via the "panel" query param', function() {
-  it('Layers is shown', async () => {
+  // Flaky on windows
+  it.skipOnPlatforms(['win32'], '[crbug.com/377280477] Layers is shown', async () => {
     await reloadDevTools({queryParams: {panel: 'layers'}});
     await tabExistsInMainPanel(LAYERS_TAB_SELECTOR);
   });