diff --git a/envs/scanorama.yaml b/envs/scanorama.yaml
index 757f9008..dc3a0adc 100644
--- a/envs/scanorama.yaml
+++ b/envs/scanorama.yaml
@@ -6,7 +6,7 @@ channels:
 dependencies:
   - python=3.9
   - scanorama=1.7.1
-  - anndata=0.7.6
+  - anndata=0.8.0
   - ca-certificates
   - openssl
   - git
diff --git a/envs/scpca-renv.post-deploy.sh b/envs/scpca-renv.post-deploy.sh
index de7d01e9..d3d94f50 100644
--- a/envs/scpca-renv.post-deploy.sh
+++ b/envs/scpca-renv.post-deploy.sh
@@ -15,6 +15,7 @@ fi
 
 
 
-
+# install packages required for renv
+Rscript --no-init-file -e 'install.packages(c("jsonlite","purrr"), repos = "https://cloud.r-project.org")'
 # restore packages
 Rscript -e 'renv::restore()'
diff --git a/envs/scpca-renv.yaml b/envs/scpca-renv.yaml
index 38147ca6..b8e470b3 100644
--- a/envs/scpca-renv.yaml
+++ b/envs/scpca-renv.yaml
@@ -8,6 +8,4 @@ dependencies:
   - pandoc
   - pkg-config
   - openssl
-  - r-base=4.1.3
-  - r-jsonlite
-  - r-purrr
+  - r-base=4.2.1
diff --git a/envs/scvi.yaml b/envs/scvi.yaml
index 1f5c3f12..912489b8 100644
--- a/envs/scvi.yaml
+++ b/envs/scvi.yaml
@@ -4,5 +4,6 @@ channels:
   - bioconda
   - defaults
 dependencies:
+  - anndata=0.8.0
   - scvi-tools=0.17.1
   - gitpython
diff --git a/renv.lock b/renv.lock
index 831a577c..be179547 100644
--- a/renv.lock
+++ b/renv.lock
@@ -1,26 +1,26 @@
 {
   "R": {
-    "Version": "4.1.3",
+    "Version": "4.2.1",
     "Repositories": [
       {
         "Name": "CRAN",
-        "URL": "https://cran.rstudio.com"
+        "URL": "https://cloud.r-project.org"
       }
     ]
   },
   "Bioconductor": {
-    "Version": "3.14"
+    "Version": "3.15"
   },
   "Packages": {
     "AnnotationDbi": {
       "Package": "AnnotationDbi",
-      "Version": "1.56.2",
+      "Version": "1.58.0",
       "Source": "Bioconductor",
       "git_url": "https://git.bioconductor.org/packages/AnnotationDbi",
-      "git_branch": "RELEASE_3_14",
-      "git_last_commit": "13fdc4a",
-      "git_last_commit_date": "2021-11-09",
-      "Hash": "ae553c2779c85946f1452919cc3e71e3",
+      "git_branch": "RELEASE_3_15",
+      "git_last_commit": "05fcf7a",
+      "git_last_commit_date": "2022-04-26",
+      "Hash": "106e57984a3dd77bd060133fa4cccf58",
       "Requirements": [
         "Biobase",
         "BiocGenerics",
@@ -41,26 +41,26 @@
     },
     "Biobase": {
       "Package": "Biobase",
-      "Version": "2.54.0",
+      "Version": "2.56.0",
       "Source": "Bioconductor",
       "git_url": "https://git.bioconductor.org/packages/Biobase",
-      "git_branch": "RELEASE_3_14",
-      "git_last_commit": "8215d76",
-      "git_last_commit_date": "2021-10-26",
-      "Hash": "767057b0e2897e2a43b59718be888ccd",
+      "git_branch": "RELEASE_3_15",
+      "git_last_commit": "3b2dd91",
+      "git_last_commit_date": "2022-04-26",
+      "Hash": "b58c1eb25be406d1a35dd4cff0e9ba2e",
       "Requirements": [
         "BiocGenerics"
       ]
     },
     "BiocFileCache": {
       "Package": "BiocFileCache",
-      "Version": "2.2.1",
+      "Version": "2.4.0",
       "Source": "Bioconductor",
       "git_url": "https://git.bioconductor.org/packages/BiocFileCache",
-      "git_branch": "RELEASE_3_14",
-      "git_last_commit": "cc91212",
-      "git_last_commit_date": "2022-01-20",
-      "Hash": "565eceff974df21115c8db7b4163ad9f",
+      "git_branch": "RELEASE_3_15",
+      "git_last_commit": "2c00eee",
+      "git_last_commit_date": "2022-04-26",
+      "Hash": "450e5bba6c68cbab059b39f88b740ade",
       "Requirements": [
         "DBI",
         "RSQLite",
@@ -74,24 +74,24 @@
     },
     "BiocGenerics": {
       "Package": "BiocGenerics",
-      "Version": "0.40.0",
+      "Version": "0.42.0",
       "Source": "Bioconductor",
       "git_url": "https://git.bioconductor.org/packages/BiocGenerics",
-      "git_branch": "RELEASE_3_14",
-      "git_last_commit": "0bc1e0e",
-      "git_last_commit_date": "2021-10-26",
-      "Hash": "ddc1d29bbe66aaef34b0d17620b61a69",
+      "git_branch": "RELEASE_3_15",
+      "git_last_commit": "3582d47",
+      "git_last_commit_date": "2022-04-26",
+      "Hash": "37348ee784e82c0a6b650146275b459d",
       "Requirements": []
     },
     "BiocIO": {
       "Package": "BiocIO",
-      "Version": "1.4.0",
+      "Version": "1.6.0",
       "Source": "Bioconductor",
       "git_url": "https://git.bioconductor.org/packages/BiocIO",
-      "git_branch": "RELEASE_3_14",
-      "git_last_commit": "c335932",
-      "git_last_commit_date": "2021-10-26",
-      "Hash": "10f50bd6daf34cd11d222befa8829635",
+      "git_branch": "RELEASE_3_15",
+      "git_last_commit": "60c8aa1",
+      "git_last_commit_date": "2022-04-26",
+      "Hash": "2f96961b653e126bfca131ede146a613",
       "Requirements": [
         "BiocGenerics",
         "S4Vectors"
@@ -107,13 +107,13 @@
     },
     "BiocNeighbors": {
       "Package": "BiocNeighbors",
-      "Version": "1.12.0",
+      "Version": "1.14.0",
       "Source": "Bioconductor",
       "git_url": "https://git.bioconductor.org/packages/BiocNeighbors",
-      "git_branch": "RELEASE_3_14",
-      "git_last_commit": "3c8a290",
-      "git_last_commit_date": "2021-10-26",
-      "Hash": "5fc6686b8fcbe45e684beecb15e3f3a5",
+      "git_branch": "RELEASE_3_15",
+      "git_last_commit": "670a1bd",
+      "git_last_commit_date": "2022-04-26",
+      "Hash": "2892f03f485df26196566e41fa490211",
       "Requirements": [
         "BiocParallel",
         "Matrix",
@@ -124,28 +124,29 @@
     },
     "BiocParallel": {
       "Package": "BiocParallel",
-      "Version": "1.28.3",
+      "Version": "1.30.3",
       "Source": "Bioconductor",
       "git_url": "https://git.bioconductor.org/packages/BiocParallel",
-      "git_branch": "RELEASE_3_14",
-      "git_last_commit": "2f9d88a",
-      "git_last_commit_date": "2021-12-07",
-      "Hash": "460c266560eefcf641c3d7c5169e5bb3",
+      "git_branch": "RELEASE_3_15",
+      "git_last_commit": "f753ae8",
+      "git_last_commit_date": "2022-06-04",
+      "Hash": "6679083c9b26ccd9f474ac5ad0bf5ea6",
       "Requirements": [
         "BH",
+        "codetools",
         "futile.logger",
         "snow"
       ]
     },
     "BiocSingular": {
       "Package": "BiocSingular",
-      "Version": "1.10.0",
+      "Version": "1.12.0",
       "Source": "Bioconductor",
       "git_url": "https://git.bioconductor.org/packages/BiocSingular",
-      "git_branch": "RELEASE_3_14",
-      "git_last_commit": "6615ae8",
-      "git_last_commit_date": "2021-10-26",
-      "Hash": "075c2e9c722f3a98268ead15cff94b63",
+      "git_branch": "RELEASE_3_15",
+      "git_last_commit": "7d1b8f4",
+      "git_last_commit_date": "2022-04-26",
+      "Hash": "33c264615f520d023d83d68880a853b8",
       "Requirements": [
         "BiocGenerics",
         "BiocParallel",
@@ -161,24 +162,24 @@
     },
     "BiocVersion": {
       "Package": "BiocVersion",
-      "Version": "3.14.0",
+      "Version": "3.15.2",
       "Source": "Bioconductor",
       "git_url": "https://git.bioconductor.org/packages/BiocVersion",
       "git_branch": "master",
-      "git_last_commit": "aa56d93",
-      "git_last_commit_date": "2021-05-19",
-      "Hash": "e57437f82a5c13263a9cf442b9796ba3",
+      "git_last_commit": "818ab03",
+      "git_last_commit_date": "2022-03-29",
+      "Hash": "48e545a2fa24a967de72b1114bfe96ac",
       "Requirements": []
     },
     "Biostrings": {
       "Package": "Biostrings",
-      "Version": "2.62.0",
+      "Version": "2.64.0",
       "Source": "Bioconductor",
       "git_url": "https://git.bioconductor.org/packages/Biostrings",
-      "git_branch": "RELEASE_3_14",
-      "git_last_commit": "53ed287",
-      "git_last_commit_date": "2021-10-26",
-      "Hash": "a2b71046a5e013f4929b85937392a1f9",
+      "git_branch": "RELEASE_3_15",
+      "git_last_commit": "c7ad3c7",
+      "git_last_commit_date": "2022-04-26",
+      "Hash": "bb0da3fab1de7f0db482b74f45bff16c",
       "Requirements": [
         "BiocGenerics",
         "GenomeInfoDb",
@@ -198,13 +199,13 @@
     },
     "DelayedArray": {
       "Package": "DelayedArray",
-      "Version": "0.20.0",
+      "Version": "0.22.0",
       "Source": "Bioconductor",
       "git_url": "https://git.bioconductor.org/packages/DelayedArray",
-      "git_branch": "RELEASE_3_14",
-      "git_last_commit": "829b529",
-      "git_last_commit_date": "2021-10-26",
-      "Hash": "8400bc4ac5cf78a44eefa2395a2ed782",
+      "git_branch": "RELEASE_3_15",
+      "git_last_commit": "4a5afd1",
+      "git_last_commit_date": "2022-04-26",
+      "Hash": "c83a6e282a9669d4e04eb2d2ce8660a8",
       "Requirements": [
         "BiocGenerics",
         "IRanges",
@@ -215,13 +216,13 @@
     },
     "DelayedMatrixStats": {
       "Package": "DelayedMatrixStats",
-      "Version": "1.16.0",
+      "Version": "1.18.0",
       "Source": "Bioconductor",
       "git_url": "https://git.bioconductor.org/packages/DelayedMatrixStats",
-      "git_branch": "RELEASE_3_14",
-      "git_last_commit": "d44a3d7",
-      "git_last_commit_date": "2021-10-26",
-      "Hash": "9ae660d2827845adeaa2fbdc3e6ad468",
+      "git_branch": "RELEASE_3_15",
+      "git_last_commit": "50c9aab",
+      "git_last_commit_date": "2022-04-26",
+      "Hash": "2d4a83550bedc8a56cc43f4327102f46",
       "Requirements": [
         "DelayedArray",
         "IRanges",
@@ -234,13 +235,13 @@
     },
     "DropletUtils": {
       "Package": "DropletUtils",
-      "Version": "1.14.2",
+      "Version": "1.16.0",
       "Source": "Bioconductor",
       "git_url": "https://git.bioconductor.org/packages/DropletUtils",
-      "git_branch": "RELEASE_3_14",
-      "git_last_commit": "945504d",
-      "git_last_commit_date": "2022-01-08",
-      "Hash": "2fd458564ca4b25deebe60541fea87c3",
+      "git_branch": "RELEASE_3_15",
+      "git_last_commit": "a08cd3b",
+      "git_last_commit_date": "2022-04-26",
+      "Hash": "c02c61d9445c825ae3c07d476569c8cd",
       "Requirements": [
         "BH",
         "BiocGenerics",
@@ -274,13 +275,13 @@
     },
     "GenomeInfoDb": {
       "Package": "GenomeInfoDb",
-      "Version": "1.30.1",
+      "Version": "1.32.3",
       "Source": "Bioconductor",
       "git_url": "https://git.bioconductor.org/packages/GenomeInfoDb",
-      "git_branch": "RELEASE_3_14",
-      "git_last_commit": "bf8b385",
-      "git_last_commit_date": "2022-01-27",
-      "Hash": "30dc66e49ea68fd50f5d3fe4b82f0533",
+      "git_branch": "RELEASE_3_15",
+      "git_last_commit": "fe2a658",
+      "git_last_commit_date": "2022-08-08",
+      "Hash": "55c3f812d79a5321d94b5f3c1178c392",
       "Requirements": [
         "BiocGenerics",
         "GenomeInfoDbData",
@@ -291,20 +292,20 @@
     },
     "GenomeInfoDbData": {
       "Package": "GenomeInfoDbData",
-      "Version": "1.2.7",
+      "Version": "1.2.8",
       "Source": "Bioconductor",
-      "Hash": "89e8144e21da34e26b7c05945cefa3ca",
+      "Hash": "b0e605ca22c2a5c6a65a3960729462da",
       "Requirements": []
     },
     "GenomicAlignments": {
       "Package": "GenomicAlignments",
-      "Version": "1.30.0",
+      "Version": "1.32.1",
       "Source": "Bioconductor",
       "git_url": "https://git.bioconductor.org/packages/GenomicAlignments",
-      "git_branch": "RELEASE_3_14",
-      "git_last_commit": "9046119",
-      "git_last_commit_date": "2021-10-26",
-      "Hash": "e1e27b5fac829942cf1359555dfbed9a",
+      "git_branch": "RELEASE_3_15",
+      "git_last_commit": "2553580",
+      "git_last_commit_date": "2022-07-21",
+      "Hash": "7d2a019a8c54d79b3455fe320cb11059",
       "Requirements": [
         "BiocGenerics",
         "BiocParallel",
@@ -319,13 +320,13 @@
     },
     "GenomicFeatures": {
       "Package": "GenomicFeatures",
-      "Version": "1.46.5",
+      "Version": "1.48.3",
       "Source": "Bioconductor",
       "git_url": "https://git.bioconductor.org/packages/GenomicFeatures",
-      "git_branch": "RELEASE_3_14",
-      "git_last_commit": "72f352e",
-      "git_last_commit_date": "2022-02-24",
-      "Hash": "4eceeebcbe30ac6e0618d090037d3af0",
+      "git_branch": "RELEASE_3_15",
+      "git_last_commit": "b0ddea0",
+      "git_last_commit_date": "2022-05-31",
+      "Hash": "b47d7c8144dd9ff029c25f8b8560efca",
       "Requirements": [
         "AnnotationDbi",
         "Biobase",
@@ -346,13 +347,13 @@
     },
     "GenomicRanges": {
       "Package": "GenomicRanges",
-      "Version": "1.46.1",
+      "Version": "1.48.0",
       "Source": "Bioconductor",
       "git_url": "https://git.bioconductor.org/packages/GenomicRanges",
-      "git_branch": "RELEASE_3_14",
-      "git_last_commit": "e422642",
-      "git_last_commit_date": "2021-11-16",
-      "Hash": "4d9cdd0c25e0c40075a2756aa78f4960",
+      "git_branch": "RELEASE_3_15",
+      "git_last_commit": "2bce608",
+      "git_last_commit_date": "2022-04-26",
+      "Hash": "07625db342974bca20a6d82dfc34386d",
       "Requirements": [
         "BiocGenerics",
         "GenomeInfoDb",
@@ -363,13 +364,13 @@
     },
     "HDF5Array": {
       "Package": "HDF5Array",
-      "Version": "1.22.1",
+      "Version": "1.24.2",
       "Source": "Bioconductor",
       "git_url": "https://git.bioconductor.org/packages/HDF5Array",
-      "git_branch": "RELEASE_3_14",
-      "git_last_commit": "b3f091f",
-      "git_last_commit_date": "2021-11-13",
-      "Hash": "04b03e15910f87fc66dc76cf5f396c7b",
+      "git_branch": "RELEASE_3_15",
+      "git_last_commit": "fb213ba",
+      "git_last_commit_date": "2022-08-01",
+      "Hash": "13693baafc480c1bb4005fe6f5e4172f",
       "Requirements": [
         "BiocGenerics",
         "DelayedArray",
@@ -383,13 +384,13 @@
     },
     "IRanges": {
       "Package": "IRanges",
-      "Version": "2.28.0",
+      "Version": "2.30.0",
       "Source": "Bioconductor",
       "git_url": "https://git.bioconductor.org/packages/IRanges",
-      "git_branch": "RELEASE_3_14",
-      "git_last_commit": "d85ee90",
-      "git_last_commit_date": "2021-10-26",
-      "Hash": "8299b0f981c924a2b824be548f836e9d",
+      "git_branch": "RELEASE_3_15",
+      "git_last_commit": "9b5f3ca",
+      "git_last_commit_date": "2022-04-26",
+      "Hash": "27d19cab80fa238e21abfbd2892120f4",
       "Requirements": [
         "BiocGenerics",
         "S4Vectors"
@@ -397,13 +398,13 @@
     },
     "KEGGREST": {
       "Package": "KEGGREST",
-      "Version": "1.34.0",
+      "Version": "1.36.3",
       "Source": "Bioconductor",
       "git_url": "https://git.bioconductor.org/packages/KEGGREST",
-      "git_branch": "RELEASE_3_14",
-      "git_last_commit": "2056750",
-      "git_last_commit_date": "2021-10-26",
-      "Hash": "01d7ab3deeee1307b7dfa8eafae2a106",
+      "git_branch": "RELEASE_3_15",
+      "git_last_commit": "1827cde",
+      "git_last_commit_date": "2022-07-08",
+      "Hash": "9dbc4322a75ffc55734070311369a8bb",
       "Requirements": [
         "Biostrings",
         "httr",
@@ -420,13 +421,13 @@
     },
     "LoomExperiment": {
       "Package": "LoomExperiment",
-      "Version": "1.12.0",
+      "Version": "1.14.0",
       "Source": "Bioconductor",
       "git_url": "https://git.bioconductor.org/packages/LoomExperiment",
-      "git_branch": "RELEASE_3_14",
-      "git_last_commit": "d254fd4",
-      "git_last_commit_date": "2021-10-26",
-      "Hash": "af38892fad0b69ed3bb6999d117f4fdf",
+      "git_branch": "RELEASE_3_15",
+      "git_last_commit": "3056093",
+      "git_last_commit_date": "2022-04-26",
+      "Hash": "47ccf5f55ea256b175a76e6a9696b752",
       "Requirements": [
         "BiocIO",
         "DelayedArray",
@@ -442,10 +443,10 @@
     },
     "MASS": {
       "Package": "MASS",
-      "Version": "7.3-58",
+      "Version": "7.3-58.1",
       "Source": "Repository",
       "Repository": "CRAN",
-      "Hash": "4bf2c61e656bbc238634c798c208d386",
+      "Hash": "762e1804143a332333c054759f89a706",
       "Requirements": []
     },
     "Matrix": {
@@ -471,13 +472,13 @@
     },
     "MatrixGenerics": {
       "Package": "MatrixGenerics",
-      "Version": "1.6.0",
+      "Version": "1.8.1",
       "Source": "Bioconductor",
       "git_url": "https://git.bioconductor.org/packages/MatrixGenerics",
-      "git_branch": "RELEASE_3_14",
-      "git_last_commit": "4588a60",
-      "git_last_commit_date": "2021-10-26",
-      "Hash": "506b92cb263d9e014a391b41939badcf",
+      "git_branch": "RELEASE_3_15",
+      "git_last_commit": "a4a2108",
+      "git_last_commit_date": "2022-06-23",
+      "Hash": "0b6a466982071e55981cf5dd8d1c3ceb",
       "Requirements": [
         "matrixStats"
       ]
@@ -537,10 +538,10 @@
     },
     "RCurl": {
       "Package": "RCurl",
-      "Version": "1.98-1.7",
+      "Version": "1.98-1.8",
       "Source": "Repository",
       "Repository": "CRAN",
-      "Hash": "b70bf7bef94b2a3fa09795b0594f3695",
+      "Hash": "19448e3b7f646a99d42660dc025e8f8c",
       "Requirements": [
         "bitops"
       ]
@@ -557,10 +558,10 @@
     },
     "RSQLite": {
       "Package": "RSQLite",
-      "Version": "2.2.14",
+      "Version": "2.2.15",
       "Source": "Repository",
       "Repository": "CRAN",
-      "Hash": "086113da6af75461b8dc8d916dcf9620",
+      "Hash": "a979a93ed3c9e7d253dd3eb870e5eb2f",
       "Requirements": [
         "DBI",
         "Rcpp",
@@ -624,14 +625,26 @@
     },
     "RcppHNSW": {
       "Package": "RcppHNSW",
-      "Version": "0.3.0",
+      "Version": "0.4.1",
       "Source": "Repository",
       "Repository": "CRAN",
-      "Hash": "ce584c040a9cfa786ffb41f938f5ed19",
+      "Hash": "a3fd7fda39fec57a7086b4fb9fa8aba3",
       "Requirements": [
         "Rcpp"
       ]
     },
+    "RcppML": {
+      "Package": "RcppML",
+      "Version": "0.3.7",
+      "Source": "Repository",
+      "Repository": "CRAN",
+      "Hash": "225157373f361daf85198a8d1ddaa733",
+      "Requirements": [
+        "Matrix",
+        "Rcpp",
+        "RcppEigen"
+      ]
+    },
     "RcppProgress": {
       "Package": "RcppProgress",
       "Version": "0.4.2",
@@ -652,13 +665,13 @@
     },
     "ResidualMatrix": {
       "Package": "ResidualMatrix",
-      "Version": "1.4.0",
+      "Version": "1.6.0",
       "Source": "Bioconductor",
       "git_url": "https://git.bioconductor.org/packages/ResidualMatrix",
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+      "Hash": "1b191143d7d3444d504277843f3a95fe",
       "Requirements": [
         "R6",
         "fs",
@@ -2515,13 +2528,13 @@
     },
     "scater": {
       "Package": "scater",
-      "Version": "1.22.0",
+      "Version": "1.24.0",
       "Source": "Bioconductor",
       "git_url": "https://git.bioconductor.org/packages/scater",
-      "git_branch": "RELEASE_3_14",
-      "git_last_commit": "ea2c95c",
-      "git_last_commit_date": "2021-10-26",
-      "Hash": "8e229c5126b386c658047881fe2e5299",
+      "git_branch": "RELEASE_3_15",
+      "git_last_commit": "013f093",
+      "git_last_commit_date": "2022-04-26",
+      "Hash": "52c6afa5fe07d6d45bcc0437565f2cef",
       "Requirements": [
         "BiocGenerics",
         "BiocNeighbors",
@@ -2531,6 +2544,7 @@
         "DelayedMatrixStats",
         "Matrix",
         "RColorBrewer",
+        "RcppML",
         "Rtsne",
         "S4Vectors",
         "SingleCellExperiment",
@@ -2560,14 +2574,14 @@
       "Package": "scpcaTools",
       "Version": "0.1.8",
       "Source": "GitHub",
-      "RemoteType": "github",
       "Remotes": "AlexsLemonade/scpcaData",
+      "RemoteType": "github",
       "RemoteHost": "api.github.com",
       "RemoteRepo": "scpcaTools",
       "RemoteUsername": "AlexsLemonade",
       "RemoteRef": "HEAD",
-      "RemoteSha": "c8e5766303959fb3f1de59c06eed6e9d87e4393f",
-      "Hash": "44343f7f4e0e7d82a9055816f9314354",
+      "RemoteSha": "a822885e536e31a5dedeb4bacfa52f5aa16ed647",
+      "Hash": "f159c999586ae1de424b052ee047c9f2",
       "Requirements": [
         "BiocGenerics",
         "DropletUtils",
@@ -2593,13 +2607,13 @@
     },
     "scran": {
       "Package": "scran",
-      "Version": "1.22.1",
+      "Version": "1.24.0",
       "Source": "Bioconductor",
       "git_url": "https://git.bioconductor.org/packages/scran",
-      "git_branch": "RELEASE_3_14",
-      "git_last_commit": "db835e3",
-      "git_last_commit_date": "2021-11-12",
-      "Hash": "2fd17063a07402b0c5b87fa27fbd6a93",
+      "git_branch": "RELEASE_3_15",
+      "git_last_commit": "c3f9e16",
+      "git_last_commit_date": "2022-04-26",
+      "Hash": "21a9c49eb50633ba6c71d7e434846d20",
       "Requirements": [
         "BH",
         "BiocGenerics",
@@ -2647,13 +2661,13 @@
     },
     "scuttle": {
       "Package": "scuttle",
-      "Version": "1.4.0",
+      "Version": "1.6.2",
       "Source": "Bioconductor",
       "git_url": "https://git.bioconductor.org/packages/scuttle",
-      "git_branch": "RELEASE_3_14",
-      "git_last_commit": "b335263",
-      "git_last_commit_date": "2021-10-26",
-      "Hash": "1c612f905434c933d27f508f294da9e0",
+      "git_branch": "RELEASE_3_15",
+      "git_last_commit": "afdfc55",
+      "git_last_commit_date": "2022-05-13",
+      "Hash": "47027fcc659e73ae827d4cebf54467e9",
       "Requirements": [
         "BiocGenerics",
         "BiocParallel",
@@ -2681,10 +2695,10 @@
     },
     "shiny": {
       "Package": "shiny",
-      "Version": "1.7.1",
+      "Version": "1.7.2",
       "Source": "Repository",
       "Repository": "CRAN",
-      "Hash": "00344c227c7bd0ab5d78052c5d736c44",
+      "Hash": "4f7970a3edb0a153ac6b376785a1944a",
       "Requirements": [
         "R6",
         "bslib",
@@ -2746,13 +2760,13 @@
     },
     "sparseMatrixStats": {
       "Package": "sparseMatrixStats",
-      "Version": "1.6.0",
+      "Version": "1.8.0",
       "Source": "Bioconductor",
       "git_url": "https://git.bioconductor.org/packages/sparseMatrixStats",
-      "git_branch": "RELEASE_3_14",
-      "git_last_commit": "78627a8",
-      "git_last_commit_date": "2021-10-26",
-      "Hash": "f8dd82d2581115df0ea380c91ed8b9f6",
+      "git_branch": "RELEASE_3_15",
+      "git_last_commit": "4f1e221",
+      "git_last_commit_date": "2022-04-26",
+      "Hash": "613693a362fb66eb32dae292b0c9e830",
       "Requirements": [
         "Matrix",
         "MatrixGenerics",
@@ -2840,10 +2854,10 @@
     },
     "statmod": {
       "Package": "statmod",
-      "Version": "1.4.36",
+      "Version": "1.4.37",
       "Source": "Repository",
       "Repository": "CRAN",
-      "Hash": "67924522fc37b515396de7d9e2408cc2",
+      "Hash": "2bbd31c2903890c6ef3204470ecfe63b",
       "Requirements": []
     },
     "stringi": {
@@ -2868,10 +2882,10 @@
     },
     "survival": {
       "Package": "survival",
-      "Version": "3.3-1",
+      "Version": "3.4-0",
       "Source": "Repository",
       "Repository": "CRAN",
-      "Hash": "f6189c70451d3d68e0d571235576e833",
+      "Hash": "04411ae66ab4659230c067c32966fc20",
       "Requirements": [
         "Matrix"
       ]
@@ -2915,12 +2929,11 @@
     },
     "tibble": {
       "Package": "tibble",
-      "Version": "3.1.7",
+      "Version": "3.1.8",
       "Source": "Repository",
       "Repository": "CRAN",
-      "Hash": "08415af406e3dd75049afef9552e7355",
+      "Hash": "56b6934ef0f8c68225949a8672fe1a8f",
       "Requirements": [
-        "ellipsis",
         "fansi",
         "lifecycle",
         "magrittr",
@@ -2976,13 +2989,13 @@
     },
     "tximport": {
       "Package": "tximport",
-      "Version": "1.22.0",
+      "Version": "1.24.0",
       "Source": "Bioconductor",
       "git_url": "https://git.bioconductor.org/packages/tximport",
-      "git_branch": "RELEASE_3_14",
-      "git_last_commit": "335213b",
-      "git_last_commit_date": "2021-10-26",
-      "Hash": "59f0784f1489e8e18d13cab597d7d813",
+      "git_branch": "RELEASE_3_15",
+      "git_last_commit": "58524f3",
+      "git_last_commit_date": "2022-04-26",
+      "Hash": "e3d09e1824fb3b3a7d36b318d09c4cba",
       "Requirements": []
     },
     "tzdb": {
@@ -3105,10 +3118,10 @@
     },
     "xfun": {
       "Package": "xfun",
-      "Version": "0.31",
+      "Version": "0.32",
       "Source": "Repository",
       "Repository": "CRAN",
-      "Hash": "a318c6f752b8dcfe9fb74d897418ab2b",
+      "Hash": "0498af3034691dde715dcd86198efe75",
       "Requirements": []
     },
     "xml2": {
@@ -3137,13 +3150,13 @@
     },
     "zellkonverter": {
       "Package": "zellkonverter",
-      "Version": "1.4.0",
+      "Version": "1.6.3",
       "Source": "Bioconductor",
       "git_url": "https://git.bioconductor.org/packages/zellkonverter",
-      "git_branch": "RELEASE_3_14",
-      "git_last_commit": "bcef367",
-      "git_last_commit_date": "2021-10-26",
-      "Hash": "fbd0f1420ccff2a085a624c5b493e145",
+      "git_branch": "RELEASE_3_15",
+      "git_last_commit": "437ff02",
+      "git_last_commit_date": "2022-06-23",
+      "Hash": "6eaa891eca5e47fddb1cb3e66fb78ed4",
       "Requirements": [
         "DelayedArray",
         "Matrix",
@@ -3157,13 +3170,13 @@
     },
     "zlibbioc": {
       "Package": "zlibbioc",
-      "Version": "1.40.0",
+      "Version": "1.42.0",
       "Source": "Bioconductor",
       "git_url": "https://git.bioconductor.org/packages/zlibbioc",
-      "git_branch": "RELEASE_3_14",
-      "git_last_commit": "3f116b3",
-      "git_last_commit_date": "2021-10-26",
-      "Hash": "3598bf6c766b0d2c15d1eefefa26d9ef",
+      "git_branch": "RELEASE_3_15",
+      "git_last_commit": "aa074d7",
+      "git_last_commit_date": "2022-04-26",
+      "Hash": "908694d02f7332d0576e7c881e572c5a",
       "Requirements": []
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     "zoo": {
diff --git a/renv/settings.dcf b/renv/settings.dcf
index 92194ffa..16670bc3 100644
--- a/renv/settings.dcf
+++ b/renv/settings.dcf
@@ -1,4 +1,4 @@
-bioconductor.version: 3.14
+bioconductor.version: 3.15
 external.libraries:
 ignored.packages:
 package.dependency.fields: Imports, Depends, LinkingTo