diff --git a/pkg/runtime/depot.go b/pkg/runtime/depot.go
index 5154fd7c97..fc42fb8af8 100644
--- a/pkg/runtime/depot.go
+++ b/pkg/runtime/depot.go
@@ -45,8 +45,11 @@ type depot struct {
 	fsMutex   *sync.Mutex
 }
 
-func newDepot() (*depot, error) {
+func newDepot(volume string) (*depot, error) {
 	depotPath := filepath.Join(storage.CachePath(), depotName)
+	if volume != "" { // Windows volume label for this depot
+		depotPath = filepath.Join(volume+"\\", "activestate", depotName)
+	}
 
 	result := &depot{
 		config: depotConfig{
diff --git a/pkg/runtime/runtime.go b/pkg/runtime/runtime.go
index 54fde6944d..2f450b271a 100644
--- a/pkg/runtime/runtime.go
+++ b/pkg/runtime/runtime.go
@@ -7,6 +7,7 @@ import (
 
 	"github.com/ActiveState/cli/internal/errs"
 	"github.com/ActiveState/cli/internal/fileutils"
+	"github.com/ActiveState/cli/internal/installation/storage"
 	"github.com/ActiveState/cli/internal/logging"
 	"github.com/ActiveState/cli/pkg/buildplan"
 	"github.com/ActiveState/cli/pkg/runtime/internal/envdef"
@@ -46,7 +47,16 @@ func New(path string) (*Runtime, error) {
 		return nil, errs.Wrap(err, "Could not create runtime directory")
 	}
 
-	depot, err := newDepot()
+	// Windows does not support hard-linking across drives, so determine if the runtime path is on a
+	// separate drive than the default depot path. If so, use a drive-specific depot path when
+	// initializing the depot.
+	runtimeVolume := filepath.VolumeName(path)
+	storageVolume := filepath.VolumeName(storage.CachePath())
+	if runtimeVolume == storageVolume {
+		runtimeVolume = ""
+	}
+
+	depot, err := newDepot(runtimeVolume)
 	if err != nil {
 		return nil, errs.Wrap(err, "Could not create depot")
 	}